St. Luke's is part of the United Church of Christ denomination.

St. Luke's belongs to the Kentuckiana Association of the Indiana-Kentucky Conference of the UCC.

Merom Camp and Conference Center is a ministry of the Indiana-Kentucky UCC. St. Luke's sends campers and counselors to camp every year, and other groups go to Merom for annual retreats.

St. Luke's helped found this Clark County social service agency in 1973, and we remain active supporters of their work in a variety of ways.

Formerly Brooklawn, Uspiritus provides comprehensive, residential care to children. St. Luke's supports them annually with school supplies, Christmas gifts and other offerings.